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Romans 9:10-13

10-13And that's not the only time. To Rebecca, also, a promise was made that took priority over genetics. When she became pregnant by our one-of-a-kind ancestor, Isaac, and her babies were still innocent in the womb—incapable of good or bad—she received a special assurance from God. What God did in this case made it perfectly plain that his purpose is not a hit-or-miss thing dependent on what we do or don't do, but a sure thing determined by his decision, flowing steadily from his initiative. God told Rebecca, "The firstborn of your twins will take second place." Later that was turned into a stark epigram: "I loved Jacob; I hated Esau."

14-18Is that grounds for complaining that God is unfair? Not so fast, please. God told Moses, "I'm in charge of mercy. I'm in charge of compassion." Compassion doesn't originate in our bleeding hearts or moral sweat, but in God's mercy. The same point was made when God said to Pharaoh, "I picked you as a bit player in this drama of my salvation power." All we're saying is that God has the first word, initiating the action in which we play our part for good or ill.